IN VIVO GENE EDITING OF MUSCLE STEM CELLS WITH ADENO-ASSOCIATED VIRAL VECTORS IN A MOUSE MODEL OF DUCHENNE MUSCULAR DYSTROPHY

In Vivo Gene Editing of Muscle Stem Cells with Adeno-Associated Viral Vectors in a Mouse Model of Duchenne Muscular Dystrophy

Delivery of therapeutic transgenes with adeno-associated viral (AAV) vectors for treatment of myopathies has yielded encouraging results in animal models and early clinical studies.Although certain AAV serotypes efficiently target muscle fibers, transduction of the muscle stem cells, also known as satellite cells, is less studied.Here, we used a Pa

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Fragments of the Liturgical-Musical Codex from the Archdiocesan Archive of Gniezno (Poland): Source Analysis and Provenance Hypotheses

This paper discusses hitherto unidentified loose folios of Poncho/Cape a parchment liturgical and musical book held in the Archdiocesan Archive of Gniezno (Poland), containing the offertory and communion antiphons for the feasts De Trinitate and Corpus Christi.The author provides the codicological description of the leaves (analyzing Latin script,

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